Endocrine Abstracts

Introduction: Patient with chronic periodontitis (CP), especially those with its advanced forms, have higher cardiovascular risk compared to those with healthy periodontium. They are also characterized by higher hs-CRP levels, greater left ventricular mass, greater intima-media thickness. Adiponectin, a hormone excreted by fat tissue, is involved in insulin sensitivity regulation and in atherosclerotic processes. The aim of the study was to assess a relationship between chroni...

Background: Nocturnal profile of GH secretion is proposed to be a screening diagnostic procedure for GH deficiency (GHD) in short children. Every screening procedure must be characterised by very high sensitivity and good specificity. The data concerning the cut-off level between normal and subnormal nocturnal GH secretion are scarce and non-consistent.The aim of the study was to assess the clinical utility of 2-h nocturnal profile of GH secretion in dia...

Background: Assessment of nocturnal GH secretion is useful tool in diagnosing GH deficiency (GHD) in children. The time period of the evaluation, the number of blood samples, as well as the choice of cut-off value for this examination – are still the matter for discussion.Aim: The aim of the study was to compare the results of 2-h and 6-h assessment of nocturnal GH secretion in children with suspected neurosecretory dysfunction of GH secretion (NSD)...

Fetal undernutrition is at the base of disorders in the differentiation process of pancreatic beta cells. Abnormal insulin activity leads to restriction of fetal growth and to obesity, insulin resistance and diabetes mellitus type 2 (DM2), either in childhood or adulthood. The aim of the study was to assess the incidence of obesity and insulin resistance in prepubertal children, born with body mass too small for their gestational age (SGA).Material and m...

95% of all cases of overt hypothyroidism are primary. It is defined as low levels of blood thyroid hormone due to disorder of the thyroid gland causing decreased synthesis and secretion of thyroid hormones. Levothyroxine is recommended as the preparation of choice for the treatment of this disease. The therapy should eliminate the symptoms of hypothyreosis, lead to the normalization of thyroid axis hormones and the avoidance of iatrogenic thyrotoxicosis. Serum TSH is the param...

Pegvisomant (PEG) is effective in acromegaly control and exerts a positive impact on glucose metabolism. The current study aimed at investigating the effects of 10-years PEG treatment on disease control, pituitary adenoma size, and metabolic profile in patients with acromegaly resistant to somatostatin analogues (SRLs). Twenty-two patients (9 men,13 women, age 45.54 ± 12.83 years) treated with PEG for 10 years, in monotherapy or in combination with SRLs, were included in ...

Pasireotide is a second-line therapy for acromegaly, that allows to obtain disease control in patients previously uncontrolled. However, pasireotide-induced hyperglycemia is of major concern. Currently, few data concerning prolonged use of pasireotide are available. The current retrospective study aimed at investigating the efficacy and safety of long-term pasireotide therapy. Sixteen consecutive patients (5 males, 11 females, age 47 ± 11 years) undergoing pasireotide for...

Some hematologic malignancies might increase the risk of fractures due to intrinsic factors of the disease but also because of the treatment with steroids or chemotherapy. The direct impact of novel targeted agents on the development of osteoporosis in these patients has not been recognized yet. A 64-years old female patient with B-cell chronic lymphocytic leukemia (B-CLL) has been followed for four years with no other comorbidities. In order to measure the burden of the disea...

Introduction: The classical triad of pheochromocytoma comprises paroxystic headache, palpitation, and diaphoresis. It is a common cause of secondary hypertension. Glycemic abnormalities are not rare. Hyperglycemia and diabetes can be the presenting features of pheochromocytoma. However, cases of hypoglycemia are also described. Malignant tumors account for about 10% of cases.Case description: In this report, we present a case of a 41-year-old man referre...

Background: Neuroendocrine tumor (NET) patients with diminished SSTR2 expre-ssion are not eligible for any type of SSTR2-specific imaging or treatment. Herein, we propose to epigenetically enhance and enable somatostatin receptor type 2 (SSTR2)-targeted theranostics for patients with NETs. Specifically, we have found that simultaneous inhibition of DNA methylation and his-tone de-ace-tylation enhanced SSTR2 expression and in vitro binding of [68Ga]DOTATATE....